
徐金标,博士,教授,硕士生导师。2014年毕业于中国科学院上海药物研究所(硕博连读),获博士学位,2025年入职浙江师范大学行知学院。从事中药材中活性成分的发现及其作用机制研究,主持国家自然科学基金1项、浙江省自然科学基金2项、市重点研发项目1项。以第一或通讯作者在Breast Cancer Research、Journal of the American Chemical Society、Phytochemistry、Journal of Ethnopharmacology、Natural Products and Bioprospecting等期刊发表SCI论文30余篇,授权发明专利4项。获浙江省科技进步奖三等奖1项,一级行业协会二等奖、三等奖各1项。浙江省151人才工程第二层次人才,浙江省高校领军人才,嘉兴市杰出人才重点资助人才。主讲《药用植物学》《中药鉴定学》《中药化学》《天然药物化学》《波谱解析》等课程。
主持项目:
1.国家自然科学基金,红豆树中金雀花碱类α4β2 nAChRs激动剂的发现、结构修饰及构效关系研究,2021.01-2023.12
2.浙江省自然科学基金,花榈木中具有神经保护作用金雀花碱类生物碱的发现及其作用机制研究,2026.01-2027.12
3.浙江省自然科学基金,畲药柳叶蜡梅中具有克服肿瘤多药耐药作用的生物碱类成分研究,2016.01-2018.12
代表论文(近五年):
1.Cheng M, Zeng XS, Yin ZY, Xie XY, Zhu JW, Wang JF, Sheng YK, Xu JB*. (+)-/(-)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Ormosia henryi Prain. Nat Prod Bioprospect. 2025, 15(1):58.
2.Zhu JW, Xu JB*, Shao ZY. Phytochemical and pharmacological properties of the genus Pseudotsuga. Fitoterapia. 2025, 183: 106528.
3.Zhan-Peng Ge#, Jin-Biao Xu#, Peng Zhao, Mai Xiang, Yu Zhou, Ze-Min Lin, Jian-Ping Zuo, Jin-Xin Zhao, Jian-Min Yue*. Highly modified cephalotane-type diterpenoids from Cephalotaxus fortunei var. alpina and C. sinensis. Phytochemistry, 2024, 221: 114038.
4.Jin Biao Xu, Jun Cao, Jin Xia, Ying Zhu, Yi He, Ming Guo Cao, Bing Mu Fang, Jean Paul Thiery, Wu Zhou*. Breast metastatic tumors in lung can be substituted by lungderived malignant cells transformed by alternative splicing H19 lncRNA. Breast Cancer Research, 2023, 25: 59.
5.Qing-Qing Zhou, Xiao-Yan Xie, Jia-Wen Zhu, Wei-Wei Pan, Bao-Gang Xie, Wu Zhou, Jin- Biao Xu*. Hosimosines A-E, structurally diverse cytisine derivatives from the seeds of Ormosia hosiei Hemsl. et Wils. Fitoterapia, 2023, 170: 105661.
6.Ruijin Geng#, Mengjie Yu#, Jinbiao Xu#, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie*. Amino acids analysis reveals serum methionine contributes to diagnosis of the Kawasaki disease in mice and children. Journal of Pharmaceutical and Biomedical Analysis, 2023, 239: 115873.
7.Xiaoyan Xie, Qingqing Zhou, Yanting Zhou, Jinbiao Xu*. The first example of di-p-methane rearrangement in nature: Cephalotanols A and B, two novel rearranged norlignan glycosides from Cephalotaxus fortunei Hook. Records of Natural Products, 2023, 17(2): 256-264.
8.Jin-Biao Xu*, Xiao-Yan Xie, Qing-Qing Zhou, Jian-Yong Zhu*. Abieshanesides A and B, two unique ent-18,19-dinoricetexane diterpenoid glycosides from Abies beshanzuensis M.H. Wu. Fitoterapia, 2022, 156: 15096.
9.Ji-Ming Wu#, Qing-Qing Zhou#, Xiao-Yan Xie, Jin-Biao Xu*; Khayalactone- and phragmalin-type limonoids with PTP1B inhibitory activity from Trichilia sinensis Bentv, Fitoterapia, 2021, 154, 105025.
10.Jin-Biao Xu#; Guang-Chun Gao#; Ming-Jing Yuan; Xuan Huang; Hong-Yu Zhou; Yang Zhang; Ya-Xin Zheng; Zhe Wu; Jun-Miao Feng; Ji-Ming Wu*; Lignans from Schisandra chinensis ameliorate alcohol induced long term liver injury and reducing hepatocellular degeneration via blocking ETBR, Journal of Ethnopharmacology, 2020, 258: 112813.
11.周青青,谢晓艳,张燕霞,周武,占扎君,徐金标*. 天然金雀花碱及其衍生物的化学结构和药理作用研究进展. 中国中药杂志, 2023, 48(10): 2679-2698.
12.蔡云欣,谢晓艳,周青青,黄雄,徐金标*. 粗榧中两个新三尖杉酯碱类成分研究,中国中药杂志,2022,47(11):2994-2999.
13.谢晓艳,周青青,朱佳雯,潘巍巍,占扎君,谢宝刚,周武,徐金标*. 冷杉属植物化学成分及其药理活性研究进展,中国药学杂志,2023,58(14):1245-1264。
授权专利:
1.中国发明专利,柳叶蜡梅中降倍半萜类化合物的制备方法(1/2),ZL202110128752.6
2.中国发明专利,用于治疗骨质疏松的中药组合物及其制备方法(1/4),ZL201510582201.1
获奖情况:
1.中国商业科技进步奖三等奖:中药复方药学研究关键技术与应用,2022.12,排序1/12
2.中国有色金属工业科技进步奖二等奖:硒元素在功能性食品中应用的关键技术及其质量控制标准,2020.12,排序8/13
3.浙江省科技进步奖三等奖:特色野生药材保护利用研究,2017,排序3/7
联系方式:
Email: xujinbiao2015@126.com

